"Do you not know that friendship with the world is enmity with God? Whoever therefore wants to be a friend of the world makes himself the enemy of God" (James 4:4). We normally do whatever we can to avoid our enemies, even to the point of fleeing from them if necessary. This reality should help us to understand why God commands us:
Do not be unequally yoked together with unbelievers. For what fellowship has righteousness with lawlessness? And what communion has light with darkness? . . . Therefore "Come out from among them and be separate, says the Lord. Do not touch what is unclean, and I will receive you." (II Corinthians 6:14, 17)
It is by means of conduct motivated by the Holy Spirit that we are to come out from among unbelievers and be separate. We cannot—we must not—straddle the fence; we cannot serve two masters. Once we are called, we must serve God, or we will have received God's grace in vain (II Corinthians 6:1).